AKTIVITAS PENGHAMBATAN ENZIM Α-GLUKOSIDASE EKSTRAK DAUN JAMBLANG (SYZYGIUM CUMINI (L.) SKEEL)

Lia Marliani, Rizki Angga Nugraha, Asep Roni

Abstract


Jamblang (Syzygium cumini (L.) Skeel) merupakan tanaman buah yang  digunakan pula dalam pengobatan tradisional. Bagian tanaman yang digunakan diantaranya adalah bagian buah, biji, dan daunnya. Salah satu penggunaan tanaman ini adalah untuk menurukan kadar gula darah pada penderita  diabetes melitus. Penghambatan aktivitas enzim α-glukosidase merupakan salah satu cara agar kadar glukosa dalam darah tetap normal. Penelitian ini bertujuan mengetahui aktivitas penghambatan enzim α-glukosidase oleh ekstrak daun jamblang. Ekstrak diperoleh dengan metode refluks menggunakan pelarut etanol 96%. Pengujian aktivitas penghambatan enzim α-glukosidase dilakukan menggunakan metode spectrophotometric stop rate determination. Pembacaan absorban dilakukan dengan menggunakan micro-plate reader pada λ 425 nm. Hasil pengujian menunjukkan nilai IC50 daun jamblang adalah 26,821 µg/mL. Hasil penapisan fitokimia menunjukkan kandungan fenol, flavonoid, tanin, quinon, saponin dan steroid/triterpenoid pada ekstrak  daun jamblang.

Keywords


Syzigium cumini (L.) skeel, α-glukosidase, ekstrak, dan fitokimia

Full Text:

PDF

References


Alam MR. et al. Evaluation of antidiabetic phytochemicals in Syzygium cumini (L.) Skeels (Family : Myrtaceae). 2012: 2(10); 94-8. Aldrich S. Enzymatic Assay of a-Glucosidase. 1996 [Diakses pada 23 Januari 2015] [Online] Available at: http://www.sigmaaldrich.com/etc/medialib/docs/sigma/general_info Ayyanar M, Subash-Babu P. Syzygium cumini (L.) Skeels : A review of its phytochemical constituents and traditional uses. Asian Pasific Journal of Tropical Biomedicine. 2012; 240-6. Bhuyan ZA, et al. Antidiabetic Effect of Syzygium cumini L. Seed on Type 2 Diabetic Rats. Dhaka Univ. J. Biol. Sci. 2010: 19(2);157-64. Bigoniya P, singh C, Srivastava B. Pharmacognostical and physico-chemical s. Asian Pacific Journal of Tropical Biomedicine. 2012; 290-5. Chisholm-Burns M, et al. Pharmacotherapy Principles and Practice. New York: Mc Graw Hill; 2008. Coman C, Rugina OD, Socaciu C. Plants and Natural Compounds with Antidiabetic Action. Not Bot Horti Agrobo. 2012: 40(1); 314-25 Dipiro JT, et al. Pharmacoteraphy: A Pathophysiologic approach. New York: Mc Graw Hill; 1999. Elansary HO, Salem MZM, Ashmawy NA, Yacout MM. Chemical Composition, Antibacterial and Antioxidant Activities of Leaves Essential Oils from Syzygium cumini L. Cupressus sempervirens L. and Lantana camara L. from Egypt. Journal of Agricultural Science. 2012: 4(10); 144-52. Farnsworth NR. Biological and Phytochemical Screening of Plants. Journal of Pharmaceutical Sciences. 1966; 55(3): 225-76. Gopinath SM, Rakesh CK, Patil GA, Dayananda K. Preliminary Phytochemical Evaluation of Leaf Extract of Euphorbia Hirta, Syzygium Cumini of Siddarabetta, Tumkur District, Karnataka. 2012: 3(2). Gowri SS, Vasantha K. Phytochemical Screening and Antibacterial Activity of Syzygium cumini (L.) (Myrtaceae) Leaves Extract. International Journal of PharmTech Research. 2010: 2(2); 1569-73. Kaskoos AR. In-vitro α-glucosidase inhibition and antioxidant activity of methanolic extract of Centaurea calcitrapa from Iraq. American Journal of Essential Oils and Natural Product. 2013: 1(1);122-5. Kumar A, et al. Anti-diabetic activity of Syzygium cumini and its isolated compound against streptozotocin-induced diabetic rats. Journal of Medicinal Plants Research. 2008: 2(9); 246-249. Kumar A, et al. Neutral components in the leaves and seeds of Syzygium cumini. African Journal of Pharmacy and Pharmacology. 2009: 3(11); 560-1. Marliani L, Kusriani H, Sari NI. Aktivitas Antioksidan Daun dan Buah Jamblang (Syzygium Cumini L.) Skeels. Bandung, Prosidding SNaPP2014 Sains, Teknologi dan Kesehatan. 2014

Oki T, Matsui T, Osajima Inhibitory effect of alpha-glucosidase inhibitors varies according to its origin. J Agric Food Chem. 1999: 47(3);550-3. Reynertson, KA, J BM, J KE. Antioxidant Potential of Seven Myrtaceous Fruit. Ethnobot Res Appl. 2005: 3; 25-35. Rekha N, Balaji R, Deecaraman M. Antihyperglycemic and antihyperlipidemic effects of extracts of the pulp of Syzygium cumini and bark of Cinnamon zeylanicum in streptozotocin-induced diabetic rats. Journal of Applied Bioscience. 2010: 28: 171830 Ruan ZP, Zhang LL, Lin YM. Evaluation of the Antioxidant Activity of Syzygium . cumini Leaves. Molecules. 2008: 13; 2545-56. Shinde J, et al. α-glukosidase Inhibitory Activity of Syzygium cumini (Linn.) Skeels seed kernel in Vitro and Goto-Kakizaki (GK) rats. Carbohydrate Research. 2008; 1278-81. Timbola A, Szpoganics B, Branco AMF, Pizzolatti M. A new flavonol from leaves of Eugenia jambolana. Fitoterapia. 2002: 73(2);174-6. Yousaf M, et al. Constitutional Composition and Allelopathic Potential of Jaman (Syzygium cumini) Leaves Against Canary Grass and Wheat. Pak. j. Weed Sci. Res. 2014: 20(3); 323-34. Zhang J, et al. α-Glucosidase Inhibitory Activity of Polyphenols from the Burs of Castanea mollissima Blume. Molecules. 2014: 19; 8373-86.