PERAN SEROTONIN DALAM PROSES PEMBELAJARAN DAN MEMORI: KAJIAN LITERATUR

Annisa Rahmah Furqaani

Abstract


Serotonin (5-HT) merupakan neurotransmiter yang telah terbukti terlibat dalam berbagai fungsi otak, termasuk proses pembelajaran dan mengingat informasi. Serotonin memegang peran penting dalam proses pembelajaran dan memori karena jalur neuron serotonergik menginervasi berbagai daerah pada sistem saraf pusat serta beragam jenis reseptor serotonin dapat ditemukan melimpah di hampir seluruh bagian otak. Keadaan ini memungkinkan serotonin memengaruhi mekanisme pembelajaran dan memori pada level seluler dan molekuler melalui beragam mekanisme bergantung pada jenis reseptor yang diaktivasinya. Serotonin diketahui dapat memengaruhi proses pembelajaran dan memori, di antaranya melalui fasilitasi sinaps dan modulasi penglepasan neurotransmiter tertentu, terlibat dalam pembentukan potensiasi jangka panjang (long-term potentiation, LTP), serta neurogenesis pada hipokampus.

Keywords


Serotonin, neurotransmiter, pembelajaran dan memori

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References


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